GIN facilities

The 4 facilities of the Grenoble Institute of Neurosciences

1) PIC GIN

The “Photonic Imaging Center of Grenoble Institute of Neuroscience” (PIC-GIN) provides imaging equipment and competencies to help you develop your scientific projects in neuroscience and life science. Several photonic microscopy techniques are available for you to study molecules, organelles, cells, whole organisms, healthy and/or diseased tissues at various scales. This platform is part of the Multidimensional Functional Microscopy Technology Network  RTMFM and a member of the GDR Imabio. It's also part of the imaging platform for life science (ISdV), which has the IBiSA ((Biology, Health and Agronomy Infrastructures) label. It is therefore open to academic users

https://neurosciences.univ-grenoble-alpes.fr/fr/recherche/plateformes-technologiques/la-plateforme-d-imagerie-photonique-pic-gin

Contact : gin-pic@univ-grenoble-alpes.fr

Yasmina Saoudi, Inserm engineer, management team, yasmina.saoudi@univ-grenoble-alpes.fr

Sara Yjjou, UGA engineer, sara.yjjou@univ-grenoble-alpes.fr

Go to the Equipments Available tab to book our instruments or use the direct links to some of them below:

Confocal Leica SPE                                    Phoenix (Videomicroscope Zeiss)                        LightSheet microscope (LaVision)  
DMI6000 Leica                                          TIRF (Nikon/Roper)                                          Confocal LSM710/Airyscan (Zeiss)
Axioscan slide scanner (Zeiss)              Spinning disk (Zeiss/Roper)                              Confocal ZEISS LSM900/Airyscan2
Stereology (MBF Biosciences)                   STEDYCON (Abberior)                                          Microscope acquisition Popov (Zeiss)

2) Electron microscopy of the Cell ( MEC)

The electron Microscopy unit belongs to the IBiSA national biological imaging network; it is therefore open to all academic users. The facility is dedicated to the ultrastructural study of cells and tissues and provides technology services as well as access to electron microscopy instruments.  The use of the instruments is on the basis of paid services and pricing follows the basic principles of INSERM supported technology services.

Ultrastructural morphological analysis are carried with the transmission electron microscope. As a facility, we provide standard specimen preparation techniques for TEM analysis, but more advanced techniques are provided though research collaboration. This include several different immunoEM methods, high-pressure freezing followed by freeze substitution, correlative light electron microscopy and 3D electron microscopy with a SEM in collaboration with Minatec. We provide training for the use of equipment and guidance for specimen preparation

Three main techniques are used on the facility: 1) Classical EPOXY embedding for morphological studies. 2) Immunogold labeling on crossection (Tokuyasu technique) to localize proteins at the ultrastructural scale. 3) Negative staining to visualize small biological samples in toto (microtubules, vesicles, exosomes, …).

https://neurosciences.ujf-grenoble.fr/recherche/plateformes-technologiques/plateforme-microscopie-electronique

 Contact : karin.pernet-gallay@univ-grenoble-alpes.fr

3) In vivo experimental facility

The different fields of activity of GIN are concerned by experiments on animals from the in vivo Experimental Facility. The overall goal of these experimental works is to link basic research and applications in human medicine in order to better understand the functioning of cells, either normal or cancerous.

https://neurosciences.univ-grenoble-alpes.fr/en/research/technological-platforms/in-vivo-experimental-platform-693749.htm?RH=NEUROEN_RECHPLAT

Go to the Equipments Available tab to book our instruments or experimental room.

Contact : magali.bartolomucci@univ-grenoble-alpes.fr

4) Virus production facility

The P2 Virology facility is a biosafety level 2 lab dedicated to the production of viral particles such as Lentivirus, Retrovirus and Adeno-associated Virus. Viruses produced on the plateform are then used for in vivo or in vitro experiments.

Contact : Julie.Brocard@univ-grenoble-alpes.fr

Contacts